After analyzing the 16 matchups on the Week 1 card in the NFL, our best against-the-spread pick is Vikings -1.5. For more suggestions, which could lead to parlay opportunities, continue reading.

NFL Picks Against the Spread – Week 1

Jump to Matchup:

Pick: Vikings -1.5 vs. Giants

• Matchup: Minnesota Vikings at New York Giants
• Projected Winner & Margin: Vikings by 3.7 points (Bet on this game at BetMGM)
• Spread: Vikings -1.5
• Time: 1:00 PM ET
• Date: September 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Packers +2.5 vs. Eagles

• Matchup: Green Bay Packers at Philadelphia Eagles
• Projected Winner & Margin: Packers by 3.8 points (Bet on this game at BetMGM)
• Spread: Eagles -2.5
• Time: 8:15 PM ET
• Date: September 6
• TV Channel: Peacock
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Cowboys +2.5 vs. Browns

• Matchup: Dallas Cowboys at Cleveland Browns
• Projected Winner & Margin: Cowboys by 0.6 points (Bet on this game at BetMGM)
• Spread: Browns -2.5
• Time: 4:25 PM ET
• Date: September 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Ravens +3 vs. Chiefs

• Matchup: Baltimore Ravens at Kansas City Chiefs
• Projected Winner & Margin: Ravens by 3.9 points (Bet on this game at BetMGM)
• Spread: Chiefs -3
• Time: 8:20 PM ET
• Date: September 5
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Colts +3 vs. Texans

• Matchup: Houston Texans at Indianapolis Colts
• Projected Winner & Margin: Colts by 0.1 points (Bet on this game at BetMGM)
• Spread: Texans -3
• Time: 1:00 PM ET
• Date: September 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Steelers +3 vs. Falcons

• Matchup: Pittsburgh Steelers at Atlanta Falcons
• Projected Winner & Margin: Steelers by 5.3 points (Bet on this game at BetMGM)
• Spread: Falcons -3
• Time: 1:00 PM ET
• Date: September 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Raiders +3 vs. Chargers

• Matchup: Las Vegas Raiders at Los Angeles Chargers
• Projected Winner & Margin: Raiders by 1.3 points (Bet on this game at BetMGM)
• Spread: Chargers -3
• Time: 4:05 PM ET
• Date: September 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Buccaneers -3 vs. Commanders

• Matchup: Washington Commanders at Tampa Bay Buccaneers
• Projected Winner & Margin: Buccaneers by 19.0 points (Bet on this game at BetMGM)
• Spread: Buccaneers -3
• Time: 4:25 PM ET
• Date: September 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Dolphins -3.5 vs. Jaguars

• Matchup: Jacksonville Jaguars at Miami Dolphins
• Projected Winner & Margin: Dolphins by 4.9 points (Bet on this game at BetMGM)
• Spread: Dolphins -3.5
• Time: 1:00 PM ET
• Date: September 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Lions -3.5 vs. Rams

• Matchup: Los Angeles Rams at Detroit Lions
• Projected Winner & Margin: Lions by 4.2 points (Bet on this game at BetMGM)
• Spread: Lions -3.5
• Time: 8:20 PM ET
• Date: September 8
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Bears -4 vs. Titans

• Matchup: Tennessee Titans at Chicago Bears
• Projected Winner & Margin: Bears by 6.6 points (Bet on this game at BetMGM)
• Spread: Bears -4
• Time: 1:00 PM ET
• Date: September 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Saints -4 vs. Panthers

• Matchup: Carolina Panthers at New Orleans Saints
• Projected Winner & Margin: Saints by 18.8 points (Bet on this game at BetMGM)
• Spread: Saints -4
• Time: 1:00 PM ET
• Date: September 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: 49ers -4 vs. Jets

• Matchup: New York Jets at San Francisco 49ers
• Projected Winner & Margin: 49ers by 22.4 points (Bet on this game at BetMGM)
• Spread: 49ers -4
• Time: 8:15 PM ET
• Date: September 9
• TV Channel: ABC/ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Broncos +6 vs. Seahawks

• Matchup: Denver Broncos at Seattle Seahawks
• Projected Winner & Margin: Seahawks by 4.2 points (Bet on this game at BetMGM)
• Spread: Seahawks -6
• Time: 4:05 PM ET
• Date: September 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bills -6.5 vs. Cardinals

• Matchup: Arizona Cardinals at Buffalo Bills
• Projected Winner & Margin: Bills by 17.9 points (Bet on this game at BetMGM)
• Spread: Bills -6.5
• Time: 1:00 PM ET
• Date: September 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bengals -8 vs. Patriots

• Matchup: New England Patriots at Cincinnati Bengals
• Projected Winner & Margin: Bengals by 14.6 points (Bet on this game at BetMGM)
• Spread: Bengals -8
• Time: 1:00 PM ET
• Date: September 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

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