What’s the best wager to make, considering each of the 16 matchups on the NFL’s Week 1 slate? Our favorite point-spread pick is Vikings -1.5, but we have lots more tips for you, which could lead to parlay opportunities, in this article.

Best Week 1 Spread Bets

Jump to Matchup:

Pick: Vikings -1.5 vs. Giants

• Matchup: Minnesota Vikings at New York Giants
• Projected Winner & Margin: Vikings by 3.7 points (Bet on this game at BetMGM)
• Spread: Vikings -1.5
• Time: 1:00 PM ET
• Date: September 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Packers +2.5 vs. Eagles

• Matchup: Green Bay Packers at Philadelphia Eagles
• Projected Winner & Margin: Packers by 3.8 points (Bet on this game at BetMGM)
• Spread: Eagles -2.5
• Time: 8:15 PM ET
• Date: September 6
• TV Channel: Peacock
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Cowboys +2.5 vs. Browns

• Matchup: Dallas Cowboys at Cleveland Browns
• Projected Winner & Margin: Cowboys by 0.6 points (Bet on this game at BetMGM)
• Spread: Browns -2.5
• Time: 4:25 PM ET
• Date: September 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Ravens +3 vs. Chiefs

• Matchup: Baltimore Ravens at Kansas City Chiefs
• Projected Winner & Margin: Ravens by 3.9 points (Bet on this game at BetMGM)
• Spread: Chiefs -3
• Time: 8:20 PM ET
• Date: September 5
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Colts +3 vs. Texans

• Matchup: Houston Texans at Indianapolis Colts
• Projected Winner & Margin: Colts by 0.1 points (Bet on this game at BetMGM)
• Spread: Texans -3
• Time: 1:00 PM ET
• Date: September 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 1 Total Bets

Jump to Matchup:

Under 47 – Ravens vs. Chiefs

• Matchup: Baltimore Ravens at Kansas City Chiefs
• Projected Total: 40.4 points (Bet on this game at BetMGM)
• Time: 8:20 PM ET
• Date: September 5
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 41.5 – Cowboys vs. Browns

• Matchup: Dallas Cowboys at Cleveland Browns
• Projected Total: 47.8 points (Bet on this game at BetMGM)
• Time: 4:25 PM ET
• Date: September 8
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 51 – Rams vs. Lions

• Matchup: Los Angeles Rams at Detroit Lions
• Projected Total: 48.6 points (Bet on this game at BetMGM)
• Time: 8:20 PM ET
• Date: September 8
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 49 – Jaguars vs. Dolphins

• Matchup: Jacksonville Jaguars at Miami Dolphins
• Projected Total: 47.6 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: September 8
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Under 44 – Jets vs. 49ers

• Matchup: New York Jets at San Francisco 49ers
• Projected Total: 40.8 points (Bet on this game at BetMGM)
• Time: 8:15 PM ET
• Date: September 9
• TV Channel: ABC/ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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